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Determination of the Antiretroviral Drug Lamivudine: by Potentiometric Titration Using All Solid State Graphite Based Iodide Selective Electrode
Ghirma Moges
Determination of the Antiretroviral Drug Lamivudine: by Potentiometric Titration Using All Solid State Graphite Based Iodide Selective Electrode
Ghirma Moges
A solid-state iodide selective electrode with Ag2S-AgI adsorbed on graphite rod, recovered from a dry cell, was prepared and validated for its typical response characteristics with an objective to develop a potentiometric titration system for rapid measurements of Lamuvidine (LMV) in tablets used as an antiretroviral drug for Hepatis B and HIV patients. The partial validationexhibited typical response values of linear range of 10-6 to 10-1 M iodide and a slope 57.57 mV/decade which reasonably agreed with early data from our Laboratory. The basis of LMV determination is its oxidation by excess bromine generated from bromate-bromide mixture. The unreacted bromine oxidized the added excess iodide to iodine. The amount of bromine consumed by LMV, the basis of its determination, was determined by subtracting the back-titrated iodine with thiosulphate whose end-point was located potentiometrically with the solid state iodide selective electrode against a reference electrode. The iodometric back titration provided for the indirect determination of 1-30 mg LMV in turbid tablet test solutions.
Media | Książki Paperback Book (Książka z miękką okładką i klejonym grzbietem) |
Wydane | 24 października 2011 |
ISBN13 | 9783846528778 |
Wydawcy | LAP LAMBERT Academic Publishing |
Strony | 60 |
Wymiary | 150 × 4 × 226 mm · 99 g |
Język | English |
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