Controlled Release Beads: Preparation and Evaluation of Controlled Release Beads of Clarithromycin

Clarithromycin has a short half life 2.5-3.0 h, is used in the treatment of H. pylori infection in stomach, which is responsible for stomach cancer, peptic ulcer and duodenal ulcer. Clarithromycin is effective against H. pylori, when it has optimum concentration at the sit of action. Gastric residence time of the conventional clarithromycin dosage form is 0.5-2 h. This work contains an attempt to made floating alginate beads of clarithromycin by using the emulsion gelation method. The overall objective is that, once the drug-carrier material has been injected or otherwise implanted or taken orally into the body the drug is released at a predetermined rate for some desired period of time.? The emulsion gelation method was successfully utilized for formulation of floating alginate beads of clarithromycin. The adopted method for estimation of clarithromycin showed good linearity. The formulated floating alginate beads have shown higher percentage of drug loading, encapsulation efficiency, particle size and very low moisture content. All work has been done at Veerayatan Institute of Pharmacy, Bhuj and KYDSCT College of Pharmacy, Sakegaon.