The Dynamic of Glucose-insulin Endocrine Metabolic Regulatory System: a System Dynamics Approach

Diabetes mellitus is a disease in the glucose-insulin endocrine metabolic regulatory system, in which the pancreas either does not release insulin or does not properly use insulin to uptake glucose in the plasma, which is referred as hyperglycemia. Complications of diabetes mellitus include retinopathy, nephropathy, peripheral neuropathy and blindness. The purpose of this study is to model the dynamic of the short-term glucose regulatory system (GRS) in man and its hormonal regulation by considering all the feedback loops which are responsible of controlling the glucose metabolism in man. The model proposed in this work used the system dynamics (SD) approach which was designed for studying complex systems. This SD model consists of twenty-three negative (balance) loops and six compartments. The model was validated during wide range of clinical test inputs, to be sure that this model accurately represents the really endocrine system. Understanding the mechanism underlying glucose-insulin oscillations and determination of the origin of the glucose¿insulin levels oscillations is another purpose of this model. Other applications for this model also have been explored.