Drug Resistance in Cancer Cells 2009 edition

Marc Notes: Includes bibliographical references and index. Jacket Description/Back: An estimated 1.5 million patients in the United States are diagnosed with cancer every year and over half-a-million individuals die of the disease. Since the vast majority of the deaths occur after medical intervention with anticancer therapy, both conventional chemotherapy and novel targeted therapy, it can be concluded that these patients die from drug resistant cancers. A growing number of studies have revealed that mechanisms underlying the development of drug resistance in cancer cells are manifold and complex and very likely are dependent on cell and microenvironment context. In view of these facts, it is important to document the mechanisms of drug resistance and understand which are the dominant resistance pathways in a particular tumor type that could provide potential therapeutic targets in a clinical setting. This book serves as a single source for the current knowledge on genetic and epigenetic alterations that contribute to the development of drug resistance. Comprehensive reviews written by renowned experts provide great insight on the current knowledge on drug resistance mechanisms. This book is a ready source of information to clinicians, cell and cancer biologists and defines molecular drug resistance mechanisms that are challenging scientists and clinical oncologists today. About Editors: Dr. Kapil Mehta is a Professor in the Department of Experimental Therapeutics, The University of Texas M. D Anderson Cancer Center, Houston, TX. He has published widely and received several patents on novel discoveries relating to drug resistance in the field of cancer therapeutics. Dr. Zahid H. Siddik is also a Professor in the Department of Experimental Therapeutics at The University of Texas M. D. Anderson Cancer Center. He has studied extensively the mechanisms of drug action and resistance, and is recognized for his seminal studies with platinum-based antitumor agents. Table of Contents: 1. Multidrug Resistance Mediated by MDR-ABC Transporters / Gergely Szakacs, Kenneth Kin Wah To, Orsolya Polgar, Robert W. Robey, Susan E. Bates -- 2. Metastasis and Drug Resistance / Dominic Fan, Sun-Jin Kim, Robert L. Langley, Isaiah J. Fidler -- 3. The Role of Autophagy and Apoptosis in the Drug Resistance of Cancer / Tomohisa Yokoyama, Yasuko Kondo, Oliver B&oumlet;gler, Seiji Kondo -- 4. Mechanisms of Resistance to Targeted Tyrosine Kinase Inhibitors / Stacey J. Baker, E. Premkumar Reddy -- 5. Targeting Transglutaminase-2 to Overcome Chemoresistance in Cancer Cells / Kapil Mehta, Jansina Y. Fok -- 6. Extracellular Matrix-Mediated Drug Resistance / P. S. Hodkinson, Tariq Sethi -- 7. Oxidative Stress and Drug Resistance in Cancer / Dunyaporn Trachootham, Wan Zhang, Peng Huang -- 8. Nuclear Factor-kB and Chemoresistance: How Intertwined Are They? / Ajaikumar B. Kunnumakkara, Preetha Anand, Bharat B. Aggarwal -- 9. Drug Resistance and the Tumor Suppressor p53: The Paradox of Wild-Type Genotype in Chemorefractory Cancers / Zahid H. Siddik -- 10. Resistance to Differentiation Therapy / Bulent Ozpolat -- 11. MicroRNAs and Drug Resistance / Elisa Barbarotto, George A. Calin -- 12. Molecular Signatures of Drug Resistance / Melissa A. Troester, Jason I. Herschkowitz, Katherine A. Hoadley -- 13. Assessment of Drug Resistance in Anticancer Therapy by Nuclear Imaging / Natalie Charnley, Catharine West, Pat Price -- 14. Overcoming Drug Resistance by Phytochemicals / Marion M. Chan, Dunne Fong -- Index. Publisher Marketing: The inability of cancer drugs to destroy metastatic tumors is the major reason why cancer therapy fails. Even though the process of drug design has become exceedingly sophisticated in recent years, there is not a single drug available that is 100 per cent effective against metastatic cancer.